Alisa Maring

I studied Biochemistry at the Goethe-University in Frankfurt am Main, where I graduated with a master’s degree in January 2018. During my master studies I did a 6-month research internship in the Group of Dr. Marc de la Roche at the Department of Biochemistry in Cambridge. Here I created a system for re-introducing the adenomatous polypopsis coliprotein (APC) into cancer cells to analyse whether WNT-signaling is a therapeutic target in colon cancer. After this internship I went back to Frankfurt to do my master thesis in the Group of Prof. Martin Zörnig at the Georg-Speyer-Haus. I investigated the transcriptional regulation of erythroid differentiation by the transcriptional regulation network consisting of FUBP1, TAL1 and c-MYC.

For my PhD I am creating 3D cell culture systems in microgels for high-thorughput screenings. In the first part of my project I am working on patient-derived colorectal cancer organoids, which are a promising tool for personalized medicine. I am trying to replace Matrigel, an ECM secreted by mouse sarcoma cells, with a fully-defined hydrogel. Moreover, I am creating a system to culture organoids together with a MMP-sensor in microgels for high-throughput screenings.

The second part of my project focuses on labelling microgels used for 3D culture with oligonucleotides for a combinatorial drug screening approach.

Interests: Cycling, rowing, cooking

Publication

[1] Steiner, M., Schneider, L., Yillah, J., Gerlach, K., Kuvardina, O. N., Meyer, A., Maring, A., Bonig, H., Seifried, E., Zörnig, M. and Lausen, J. (2019). FUSE binding protein 1 (FUBP1) expression is upregulated by T-cell acute lymphocytic leukemia protein 1 (TAL1) and required for efficient erythroid differentiation. PLoS ONE 14, e0210515. 10.1371/journal.pone.0210515. Link.