Post-Doc
Joined the lab: August 2022
Background and Current Project: Following an B.Sc. and M.Sc. in Biochemistry at the Freie Universität Berlin, I did my PhD in early mouse and human embryogenesis focussing at the time point of implantation during which the embryo forms its first contacts with the maternal endometrium. At that stage, the embryo undergoes a series of remodelling events while transforming from its pre- into its post-implantation configuration. During my PhD in the group of Magdalena Zernicka-Goetz, I carried out numerous projects focussing on different aspects of this transformation process in both mouse and human embryos. For my PostDoc, I would like to examine non-coding RNA dynamics of early mouse embryogenesis using the recently developed VASA-Seq method. In addition, I aim to understand the evolution of the pluripotency gene regulatory network across the phylogenetic tree in amniotes with the aim to eventually lay the basis for the generation of naïve pluripotent stem cells of endangered species.
Interests: When not in the lab, you will find me doing fine art using different techniques - from painting with pure ash to elaborate copper etchings ranging from naturalistic to abstract - or writing poetry or one of my novels. “EWIGKEIT” (eternity), the first exhibition of my paintings, took place 2014-2015 at the publishing company Mittelbayerische Zeitung. Currently, I am working on my second exhibition. My poems have been published in numerous anthologies and I am currently working on the publication on my first novel “Leopold, der Junge am See” (Leopold, the boy at the lake).
First Authorship
- Molè MA*, Coorens THH*, Shahbazi MN*, Weberling A*, Weatherbee BAT*, Gantner C, Sancho-Serra C, Richardson L, Drinkwater A, Syed N, Engley S, Snell P, Christie L, Elder K, Campbell A, Fishel S, Vento-Tormo R, Behjati S & Zernicka-Goetz M: A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre. Nature Communications. 2021 doi: 10.1038/s41467-021-23758-w (*equal contribution)
- Molè MA*, Weberling A*, Shahbazi MN, Fässler R, Campbell A, Fishel S & Zernicka-Goetz M: Integrin beta1 coordinates embryo survival and morphogenesis upon implantation and pluripotency transition. Cell Reports. 2021 doi: 10.1016/j.celrep.2021.108834 (*equal contribution)
- Weberling A & Zernicka-Goetz M: Trophectoderm mechanics direct epiblast shape upon embryo implantation. Cell Reports. 2021 doi: 10.1016/j.celrep.2020.108655
- Molè MA*, Weberling A* & Zernicka-Goetz M: Comparative analysis of human and mouse development - from zygote to pre-gastrulation. Review. Current Topics in Developmental Biology. 2020 doi: 10.1016/bs.ctdb.2019.10.002 (*equal contribution)
- Christodoulou N*, Weberling A*, Strathdee D, Anderson KI, Timpson P & Zernicka-Goetz M: Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation. Nature Communications. 2019 doi: 10.1038/s41467-019-11482-5. (*equal contribution)
Authorship
- Liang X, Weberling A, Hii, CY, Zernicka-Goetz M & Buckley C: E-cadherin mediated Apical Membrane Initiation Site localisation. The EMBO Journal 2022, in press
- Liang X, Weberling A, Hii CY, Zernicka-Goetz M & Buckley C: CADHERIN mediated AMIS localisation. biorxiv 2021, doi: 10.1101/2021.11.30.470571
- Kósa B, Mikula K, Markjoe Uba M, Weberling A, Christodoulou N & Zernicka-Goetz M: 3D Image Segmentation Supported By A Point Cloud. Discrete and Continuous Dynamical Systems Series S. 2021 doi: 10.3934/dcdss.2020351
- Molè MA, Galea GL, Rolo A, Weberling A, Nychyk O, Castro SC, Savery D, Fässler R, Ybot- González P, Greene NDE, Copp AJ: Integrin-mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure. Developmental Cell. 2020 doi: 10.1016/j.devcel.2020.01.012.
- Christodoulou N, Kyprianou C, Weberling A, Wang R, Cui G, Peng G, Jing N & Zernicka-Goetz M: Sequential formation and resolution of multiple rosettes drives embryo remodeling after implantation. Nature Cell Biology. 2018 doi: 10.1038/s41556-018-0211-3.
- Shahbazi MN, Scialdone A, Skorupska N, Weberling A, Recher G, Zhu M, Jedrusik A, Devito LG, Noli L, Macaulay IC, Buecker C, Khalaf Y, Ilic D, Voet T, Marioni JC, & Zernicka-Goetz M: Naïve pluripotency exit directs pro-amniotic cavity formation in mouse and human embryos. Nature. 2017 doi: 10.1038/nature24675.
- Lock FE, Babaian A, Zhang Y, Gagnier L, Kuah S, Weberling A, Karimi MM, & Mager DL: A novel isoform of IL-33 revealed by screening for transposable element promoted genes in human colorectal cancer. PLoS One. 2017 doi: 10.1371/journal.pone.0180659.
