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Hollfelder Group

Ph.D

Joined the Hollfelder group:  Summer 2018

Background and Current Projects: Before starting university, I attended a chemistry-focused higher vocational school (HBLVA Rosensteingasse) in Vienna and afterwards spent a year in the Bundesheer, mainly in the chemical laboratories (ARWT). I first joined the Hollfelder lab as a summer student in 2018 after my third year of undergraduate studies in Cambridge. During this time I put my long standing interest in chemical mechanism to good use, participating in an enzymological study of an unusual phosphotriesterase. The year after, I again joined as a summer student, now working on captivases, before starting my own PhD research. Currently, my main focus is centred on the generation and directed evolution of artificial metalloenzymes containing organometallic cofactors. Due to the interdisciplinary nature of the project, I am found in both the chemistry and biochemistry departments.

Interests: Fencing, Skiing, Hiking, Festivals, Beer

 

Publications 

[3] GS Biggs*, OJ Klein*, SL Maslen, JM Skehel, TJ Rutherford, SMV Freund, F Hollfelder, SR Boss, PD Barker. Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation . Angew Chem Int Ed (2021), 60, 10919 . Link

[2] GS Biggs*, OJ Klein*, SR Boss, PD Barker. Unlocking the Full Evolutionary Potential of Artificial Metalloenzymes Through Direct Metal-Protein Coordination: A review of recent advances for catalyst development. Johnson Matthey Technology Review (2020), 64, 407. Link

[1] M Schöbinger, OJ Klein, G Mitulović . Low-Temperature Mobile Phase for Peptide Trapping at Elevated Separation Temperature Prior to Nano RP-HPLC-MS/MS. Separations (2016), 3, 6. Link

 

Contact Details

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge CB2 1EW

Job Title

Ph.D. student