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Hollfelder Group

Ph.D

Joined the Hollfelder group: October 2019

Background and Current Projects: Max was born in Toronto, Canada and raised in Oslo, Norway. His name is a pun in Norwegian, meaning maximum joy or good fortune, we hope he stays true to his name. He obtained his bachelor degree in Molecular Biology from the University of Oslo with an exchange at UCSD, where a course on stem cell biology encouraged him to pursue further research in this field. On returning to Oslo, he began his master’s project in Gareth Sullivan’s lab at the Norwegian Center for Stem Cell Research. His work focused on the cell signalling behind differentiation towards definitive endoderm in human pluripotent stem cells. He continued working in the Sullivan lab after his master’s thesis was submitted, followed by a year working as a research assistant in the Krauss Group at the Hybrid Technology Hub, University of Oslo. This work focused on the responsiveness of cancer cell lines to a drug called G007-LK, a potent tankyrase inhibitor. He then worked for a year in the Choudhary Group at the Novo Nordisk Foundation Center for Protein Research in Copenhagen, gaining experience in cell line editing for proteomic analysis. Max is jointly supervised by the Hollfelder and Boroviak labs for his PhDand will be developing gel encapsulated 3D models of gastrulation

 

Publications

[6] Line Mygland, Shoshy Alam Brinch, Martin Frank Strand, Petter Angell Olsen, Aleksandra Aizenshtadt, KajaLund, Nina Therese Solberg, MaxLycke, Tor Espen Thorvaldsen, Sandra Espada, Dorna Misaghian, Christian M. Page, Oleg Agafonov, Ståle Nygård, Nai-Wen Chi, Eva Lin, Jenille Tan, Yihong Yu, Mike Costa, Stefan Krauss, JoWaaler. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience (2021). Link

[5] Jo Waaler, Ruben G. G. Leenders, Sven T. Sowa, Shoshy Alam Brinch, Max Lycke, Piotr Nieczypor, Sjoerd Aertssen, Sudarshan Murthy, Albert Galera-Prat, Eddy Damen, Anita Wegert, Marc Nazaré, Lari Lehtiö, and Stefan Krauss Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor Journal of Medicinal Chemistry(2020).Link

[4] Jo Waaler, Line Mygland, Anders Tveita, Martin Frank Strand, Nina Therese Solberg, Petter Angell Olsen, Aleksandra Aizenshtadt, Marte Fauskanger, Kaja Lund, Shoshy Alam Brinch, Max Lycke, Elisabeth Dybing, Vegard Nygaard, Sigurd Læines Bøe, Karen-Marie Heintz, Eivind Hovig, Clara Hammarström, Alexandre Corthay & Stefan Krauss - Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.Communications Biology (2020).Link

[3] Richard Siller, Eric Dufour, Max Lycke, Ian Wilmut, Yong-Wook Jung, In Hyun Park Gareth J.Sullivan. Development of an inducible platform for intercellular protein delivery. International Journal of Pharmaceutics (2017).Link

[2] Richard Siller, Elena Naumovska, Santosh Mathapati, Max Lycke, Sebastian Greenhough & Gareth J. Sullivan. Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines. Scientific Reports (2016). Link

[1] Santosh Mathapati,Richard Siller,Agata A.R. Impellizzeri,Max Lycke,Karianne Vegheim,Runar Almaas,Gareth J. Sullivan. Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells. Current Protocols in Stem Cell Biology (2016). Link

 

Contact Details

Department for Physiology
Development and Neuroscience Physiology Building
G-Floor Downing Street
Cambridge CB2 3EG
Email: eml60@cam.ac.uk